Epigenetic Control of Immunity | Zendy

Meinrad Busslinger | Zendy; A. Tarakhovsky | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Epigenetic Control of Immunity

Author(s) -

Meinrad Busslinger,

A. Tarakhovsky

Publication year - 2014

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a019307

Subject(s) - biology , immune system , acquired immune system , epigenetics , immunity , immunology , innate immune system , innate lymphoid cell , ccl18 , genetics , gene

Immunity relies on the heterogeneity of immune cells and their ability to respond to pathogen challenges. In the adaptive immune system, lymphocytes display a highly diverse antigen receptor repertoire that matches the vast diversity of pathogens. In the innate immune system, the cell's heterogeneity and phenotypic plasticity enable flexible responses to changes in tissue homeostasis caused by infection or damage. The immune responses are calibrated by the graded activity of immune cells that can vary from yeast-like proliferation to lifetime dormancy. This article describes key epigenetic processes that contribute to the function of immune cells during health and disease.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research