Expanding the Epigenetic Landscape: Novel Modifications of Cytosine in Genomic DNA | Zendy

Skirmantas Kriaučionis | Zendy; Mamta Tahiliani | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Expanding the Epigenetic Landscape: Novel Modifications of Cytosine in Genomic DNA

Author(s) -

Skirmantas Kriaučionis,

Mamta Tahiliani

Publication year - 2014

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a018630

Subject(s) - biology , epigenetics , library science , dna methylation , computational biology , genetics , gene , computer science , gene expression

Methylation of the base cytosine in DNA is critical for silencing endogenous retroviruses, regulating gene expression, and establishing cellular identity, and has long been regarded as an indelible epigenetic mark. The recent discovery that the ten eleven translocation (TET) proteins can oxidize 5-methylcytosine (5mC) resulting in the formation of 5-hydroxymethylcytosine (5hmC) and other oxidized cytosine variants in the genome has triggered a paradigm shift in our understanding of how dynamic changes in DNA methylation regulate transcription and cellular differentiation, thus influencing normal development and disease

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research