lncRNAs: Linking RNA to Chromatin | Zendy

John L. Rinn | Zendy

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lncRNAs: Linking RNA to Chromatin

Author(s) -

John L. Rinn

Publication year - 2014

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a018614

Subject(s) - biology , epigenetics , chromatin , interfacing , computational biology , epigenesis , rna , genome , long non coding rna , genetics , non coding rna , dna methylation , gene expression , gene , computer science , computer hardware

Numerous studies over the past decade have identified increasing numbers of long noncoding RNAs (lncRNAs) across many organisms. Research since has shown that lncRNAs constitute an important layer of genome regulation in diverse biological processes and disease. Here, we discuss the common emerging theme of lncRNAs interfacing with epigenetic machinery. This, in turn, modulates the activity and localization of the epigenetic machinery during cell fate specification.

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