Cellular Reprogramming | Zendy

Kazutoshi Takahashi | Zendy

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Cellular Reprogramming

Author(s) -

Kazutoshi Takahashi

Publication year - 2014

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a018606

Subject(s) - reprogramming , biology , induced pluripotent stem cell , regenerative medicine , epigenetics , somatic cell , stem cell , embryonic stem cell , microbiology and biotechnology , genetics , cell , gene

Nuclear reprogramming technology was first established more than 50 years ago. It can rejuvenate somatic cells by erasing the epigenetic memories and reconstructing a new pluripotent order. The recent discovery reviewed here that induced pluripotency can be achieved by a small set of transcription factors has opened up unprecedented opportunities in the pharmaceutical industry, the clinic, and laboratories. This technology allows us to access pathological studies by using patient-specific induced pluripotent stem (iPS) cells. In addition, iPS cells are also expected to be a rising star for regenerative medicine, as sources of transplantation therapy.

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