Regulation of the X Chromosomes in Caenorhabditis elegans | Zendy

Susan Strome | Zendy; William G. Kelly | Zendy; Sevinç Ercan | Zendy; Jason D. Lieb | Zendy

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Regulation of the X Chromosomes in Caenorhabditis elegans

Author(s) -

Susan Strome,

William G. Kelly,

Sevinç Ercan,

Jason D. Lieb

Publication year - 2014

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a018366

Subject(s) - biology , dosage compensation , caenorhabditis elegans , chromatin , xist , x inactivation , genetics , x chromosome , germline , gene , somatic cell , caenorhabditis , epigenetics , chromosome , microbiology and biotechnology

Dosage compensation, which regulates the expression of genes residing on the sex chromosomes, has provided valuable insights into chromatin-based mechanisms of gene regulation. The nematode Caenorhabditis elegans has adopted various strategies to down-regulate and even nearly silence the X chromosomes. This article discusses the different chromatin-based strategies used in somatic tissues and in the germline to modulate gene expression from the C. elegans X chromosomes and compares these strategies to those used by other organisms to cope with similar X-chromosome dosage differences.

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