Specialists and Generalists: The Sexual Ecology of the Genome | Zendy

David Haig | Zendy; Francisco Úbeda | Zendy; Manus M. Patten | Zendy

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Specialists and Generalists: The Sexual Ecology of the Genome

Author(s) -

David Haig,

Francisco Úbeda,

Manus M. Patten

Publication year - 2014

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a017525

Subject(s) - biology , genetics , allele , linkage disequilibrium , gene , evolutionary biology , haplotype

Sexual antagonism occurs when an allele is beneficial in one sex but costly in the other. Parental antagonism occurs when an allele is beneficial when inherited from one sex but costly when inherited from the other because of fitness interactions among kin. Sexual and parental antagonisms together define four genetic niches within the genome that favor different patterns of gene expression. Natural selection generates linkage disequilibrium among sexually and parentally antagonistic loci with male-beneficial alleles coupled to alleles that are beneficial when inherited from males and female-beneficial alleles coupled to alleles that are beneficial when inherited from females. Linkage disequilibrium also develops between sexually and parentally antagonistic loci and loci that influence sex determination. Genes evolve sex-specific expression to resolve sexual antagonism and evolve imprinted expression to resolve parental antagonism. Sex-specific chromosomes allow a gene to specialize in a single niche.

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