The Complex Ultrastructure of the Endolysosomal System | Zendy

Judith Klumperman | Zendy; Graça Raposo | Zendy

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The Complex Ultrastructure of the Endolysosomal System

Author(s) -

Judith Klumperman,

Graça Raposo

Publication year - 2014

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a016857

Subject(s) - biology , marie curie , ultrastructure , center (category theory) , anatomy , chemistry , european union , business , crystallography , economic policy

Live-cell imaging reveals the endolysosomal system as a complex and highly dynamic network of interacting compartments. Distinct types of endosomes are discerned by kinetic, molecular, and morphological criteria. Although none of these criteria, or combinations thereof, can capture the full complexity of the endolysosomal system, they are extremely useful for experimental purposes. Some membrane domain specializations and specific morphological characteristics can only be seen by ultrastructural analysis after preparation for electron microscopy (EM). Immuno-EM allows a further discrimination of seemingly identical compartments by their molecular makeup. In this review we provide an overview of the ultrastructural characteristics and membrane organization of endosomal compartments, along with their organizing machineries.

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