The Biogenesis of Lysosomes and Lysosome-Related Organelles | Zendy

J. Paul Luzio | Zendy; Yvonne Hackmann | Zendy; Nele M. G. Dieckmann | Zendy; Gillian M. Griffiths | Zendy

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The Biogenesis of Lysosomes and Lysosome-Related Organelles

Author(s) -

J. Paul Luzio,

Yvonne Hackmann,

Nele M. G. Dieckmann,

Gillian M. Griffiths

Publication year - 2014

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a016840

Subject(s) - lysosome , organelle , biology , microbiology and biotechnology , biogenesis , endocytosis , organelle biogenesis , secretion , cytoplasm , autophagy , tfeb , cell , biochemistry , apoptosis , gene , enzyme

Lysosomes were once considered the end point of endocytosis, simply used for macromolecule degradation. They are now recognized to be dynamic organelles, able to fuse with a variety of targets and to be re-formed after fusion events. They are also now known to be the site of nutrient sensing and signaling to the cell nucleus. In addition, lysosomes are secretory organelles, with specialized machinery for regulated secretion of proteins in some cell types. The biogenesis of lysosomes and lysosome-related organelles is discussed, taking into account their dynamic nature and multiple roles.

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