Molecular Mechanisms of the Membrane Sculpting ESCRT Pathway | Zendy

W. Mike Henne | Zendy; Harald Stenmark | Zendy; Scott D. Emr | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Molecular Mechanisms of the Membrane Sculpting ESCRT Pathway

Author(s) -

W. Mike Henne,

Harald Stenmark,

Scott D. Emr

Publication year - 2013

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a016766

Subject(s) - escrt , biology , cytokinesis , microbiology and biotechnology , endosome , abscission , transport protein , biogenesis , aaa proteins , atpase , cell division , cell , biochemistry , genetics , intracellular , gene , enzyme

The endosomal sorting complexes required for transport (ESCRT) drive multivesicular body (MVB) biogenesis and cytokinetic abscission. Originally identified through genetics and cell biology, more recent work has begun to elucidate the molecular mechanisms of ESCRT-mediated membrane remodeling, with special focus on the ESCRT-III complex. In particular, several light and electron microscopic studies provide high-resolution imaging of ESCRT-III rings and spirals that purportedly drive MVB morphogenesis and abscission. These studies highlight unifying principles to ESCRT-III function, in particular: (1) the ordered assembly of the ESCRT-III monomers into a heteropolymer, (2) ESCRT-III as a dynamic complex, and (3) the role of the AAA ATPase Vps4 as a contributing factor in membrane scission. Mechanistic comparisons of ESCRT-III function in MVB morphogenesis and cytokinesis suggest common mechanisms in membrane remodeling.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research