DNA Strand Exchange and RecA Homologs in Meiosis | Zendy

Michael S. Brown | Zendy; Douglas K. Bishop | Zendy

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DNA Strand Exchange and RecA Homologs in Meiosis

Author(s) -

Michael S. Brown,

Douglas K. Bishop

Publication year - 2014

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a016659

Subject(s) - homologous chromosome , rad51 , biology , homologous recombination , meiosis , synaptonemal complex , sister chromatids , genetics , chromosomal crossover , chromatid , genetic recombination , dna , homology (biology) , establishment of sister chromatid cohesion , recombination , homology directed repair , cohesin , microbiology and biotechnology , dna repair , chromosome , gene , dna mismatch repair

Homology search and DNA strand-exchange reactions are central to homologous recombination in meiosis. During meiosis, these processes are regulated such that the probability of choosing a homolog chromatid as recombination partner is enhanced relative to that of choosing a sister chromatid. This regulatory process occurs as homologous chromosomes pair in preparation for assembly of the synaptonemal complex. Two strand-exchange proteins, Rad51 and Dmc1, cooperate in regulated homology search and strand exchange in most organisms. Here, we summarize studies on the properties of these two proteins and their accessory factors. In addition, we review current models for the assembly of meiotic strand-exchange complexes and the possible mechanisms through which the interhomolog bias of recombination partner choice is achieved.

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