DNA Degradation and Its Defects | Zendy

Kohki Kawane | Zendy; Kou Motani | Zendy; Shigekazu Nagata | Zendy

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DNA Degradation and Its Defects

Author(s) -

Kohki Kawane,

Kou Motani,

Shigekazu Nagata

Publication year - 2014

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a016394

Subject(s) - biology , dna , mechanism (biology) , function (biology) , cytosol , nucleotide , biochemistry , microbiology and biotechnology , computational biology , genetics , gene , enzyme , philosophy , epistemology

DNA is one of the most essential molecules in organisms, containing all the information necessary for organisms to live. It replicates and provides a mechanism for heredity and evolution. Various events cause the degradation of DNA into nucleotides. DNA also has a darker side that has only recently been recognized; DNA that is not properly degraded causes various diseases. In this review, we discuss four deoxyribonucleases that function in the nucleus, cytosol, and lysosomes, and how undigested DNA causes such diseases as cancer, cataract, and autoinflammation. Studies on the biochemical and physiological functions of deoxyribonucleases should continue to increase our understanding of cellular functions and human diseases.

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