Emergent Properties of the Metaphase Spindle | Zendy

Simone Reber | Zendy; Anthony A. Hyman | Zendy

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Emergent Properties of the Metaphase Spindle

Author(s) -

Simone Reber,

Anthony A. Hyman

Publication year - 2015

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a015784

Subject(s) - biology , kinetochore , metaphase , spindle apparatus , microtubule , spindle pole body , function (biology) , chromosome segregation , microbiology and biotechnology , spindle checkpoint , chromatin , computational biology , chromosome , genetics , cell division , cell , dna , gene

A metaphase spindle is a complex structure consisting of microtubules and a myriad of different proteins that modulate microtubule dynamics together with chromatin and kinetochores. A decade ago, a full description of spindle formation and function seemed a lofty goal. Here, we describe how work in the last 10 years combining cataloging of spindle components, the characterization of their biochemical activities using single-molecule techniques, and theory have advanced our knowledge. Taken together, these advances suggest that a full understanding of spindle assembly and function may soon be possible.

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