Replication Proteins and Human Disease | Zendy

Andrew P. Jackson | Zendy; R. A. Laskey | Zendy; Nicholas Coleman | Zendy

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Replication Proteins and Human Disease

Author(s) -

Andrew P. Jackson,

R. A. Laskey,

Nicholas Coleman

Publication year - 2013

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a013060

Subject(s) - biology , kingdom , human genetics , library science , replication (statistics) , human disease , anthropology , genetics , sociology , gene , virology , paleontology , computer science

In this article, we discuss the significance of DNA replication proteins in human disease. There is a broad range of mutations in genes encoding replication proteins, which result in several distinct clinical disorders that share common themes. One group of replication proteins, the MCMs, has emerged as effective biomarkers for early detection of a range of common cancers. They offer practical and theoretical advantages over other replication proteins and have been developed for widespread clinical use.

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