Herpes Simplex Viruses: Mechanisms of DNA Replication | Zendy

Sandra K. Weller | Zendy; Donald M. Coen | Zendy

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Herpes Simplex Viruses: Mechanisms of DNA Replication

Author(s) -

Sandra K. Weller,

Donald M. Coen

Publication year - 2012

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a013011

Subject(s) - biology , single stranded binding protein , dna replication , primase , virology , replication protein a , dna polymerase , replication factor c , dna , dna binding protein , helicase , viral replication , genetics , eukaryotic dna replication , virus , polymerase chain reaction , gene , reverse transcriptase , rna , transcription factor

Herpes simplex virus (HSV) encodes seven proteins necessary for viral DNA synthesis-UL9 (origin-binding protein), ICP8 (single-strand DNA [ssDNA]-binding protein), UL30/UL42 (polymerase), and UL5/UL8/UL52 (helicase/primase). It is our intention to provide an up-to-date analysis of our understanding of the structures of these replication proteins and how they function during HSV replication. The potential roles of host repair and recombination proteins will also be discussed.

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