Adenovirus DNA Replication | Zendy

Rob C. Hoeben | Zendy; Taco G. Uil | Zendy

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Adenovirus DNA Replication

Author(s) -

Rob C. Hoeben,

Taco G. Uil

Publication year - 2013

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a013003

Subject(s) - biology , oncolytic virus , virology , dna replication , computational biology , viral replication , gene transfer , gene , virus , genetics

Adenoviruses have attracted much attention as probes to study biological processes such as DNA replication, transcription, splicing, and cellular transformation. More recently these viruses have been used as gene-transfer vectors and oncolytic agents. On the other hand, adenoviruses are notorious pathogens in people with compromised immune functions. This article will briefly summarize the basic replication strategy of adenoviruses and the key proteins involved and will deal with the new developments since 2006. In addition, we will cover the development of antivirals that interfere with human adenovirus (HAdV) replication and the impact of HAdV on human disease.

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