Human Papillomavirus Infections: Warts or Cancer? | Zendy

Louise T. Chow | Zendy; Thomas R. Broker | Zendy

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Human Papillomavirus Infections: Warts or Cancer?

Author(s) -

Louise T. Chow,

Thomas R. Broker

Publication year - 2013

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a012997

Subject(s) - biology , common warts , human papillomavirus , papillomaviridae , cancer , virology , hpv infection , epidermodysplasia verruciformis , cancer research , immunology , virus , pathology , cervical cancer , medicine , genetics

Human papillomaviruses (HPVs) are prevalent pathogens of mucosal and cutaneous epithelia. Productive infections of squamous epithelia lead to benign hyperproliferative warts, condylomata, or papillomas. Persistent infections of the anogenital mucosa by high-risk HPV genotypes 16 and 18 and closely related types can infrequently progress to high-grade intraepithelial neoplasias, carcinomas-in-situ, and invasive cancers in women and men. HPV-16 is also associated with a fraction of head and neck cancers. We discuss the interactions of the mucosotropic HPVs with the host regulatory proteins and pathways that lead to benign coexistence and enable HPV DNA amplification or, alternatively, to cancers that no longer support viral production.

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