Repair of Strand Breaks by Homologous Recombination | Zendy

Maria Jasin | Zendy; Rodney Rothstein | Zendy

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Repair of Strand Breaks by Homologous Recombination

Author(s) -

Maria Jasin,

Rodney Rothstein

Publication year - 2013

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a012740

Subject(s) - biology , homologous recombination , recombination , homologous chromosome , genetics , computational biology , evolutionary biology , dna , gene

In this review, we discuss the repair of DNA double-strand breaks (DSBs) using a homologous DNA sequence (i.e., homologous recombination [HR]), focusing mainly on yeast and mammals. We provide a historical context for the current view of HR and describe how DSBs are processed during HR as well as interactions with other DSB repair pathways. We discuss the enzymology of the process, followed by studies on DSB repair in living cells. Whenever possible, we cite both original articles and reviews to aid the reader for further studies.

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