Open AccessPI3K-PKB/Akt Pathway
Author(s) -
Brian A. Hemmings,
David F. Restuccia
Publication year - 2012
Publication title -
cold spring harbor perspectives in biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.011
H-Index - 173
ISSN - 1943-0264
DOI - 10.1101/cshperspect.a011189
Subject(s) - protein kinase b , biology , pi3k/akt/mtor pathway , microbiology and biotechnology , phosphoinositide 3 kinase , kinase , proto oncogene proteins c akt , cell growth , signal transduction , biochemistry
Protein kinase B (PKB, or Akt) plays a role in cell metabolism, growth, proliferation, and survival. Its activation is controlled by a multi-step process that involves phosphoinositide-3-kinase (PI3K).
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