Calcium Signaling | Zendy

Martin D. Bootman | Zendy

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Calcium Signaling

Author(s) -

Martin D. Bootman

Publication year - 2012

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a011171

Subject(s) - biology , calcium , calcium signaling , signal transduction , computational biology , microbiology and biotechnology , medicine

Calcium ions regulate processes as diverse as cell motility, gene transcription, muscle contraction, and exocytosis (Berridge et al. 2000). The first realization that they are critical for cellular function is often attributed to Sydney Ringer, who discovered in 1883 that saline solution made up using London tap water (which contained calcium) supported the contraction of isolated frog hearts, whereas saline made up using distilled water (which lacked calcium) could not. Subsequent work revealed that numerous cell biological processes are controlled by calcium (Carafoli

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