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Spatio-Temporal Organization of Replication in Bacteria and Eukaryotes (Nucleoids and Nuclei)
Author(s) -
Daniel J. Jackson,
Xindan Wang,
David Z. Rudner
Publication year - 2012
Publication title -
cold spring harbor perspectives in biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.011
H-Index - 173
ISSN - 1943-0264
DOI - 10.1101/cshperspect.a010389
Subject(s) - biology , replication (statistics) , nucleoid , dna replication , origin recognition complex , origin of replication , replication timing , licensing factor , pre replication complex , control of chromosome duplication , three domain system , evolutionary biology , genetics , bacteria , eukaryotic dna replication , dna , archaea , gene , escherichia coli , virology
Here we discuss the spatio-temporal organization of replication in eubacteria and eukaryotes. Although there are significant differences in how replication is organized in cells that contain nuclei from those that do not, you will see that organization of replication in all organisms is principally dictated by the structured arrangement of the chromosome. We will begin with how replication is organized in eubacteria with particular emphasis on three well studied model organisms. We will then discuss spatial and temporal organization of replication in eukaryotes highlighting the similarities and differences between these two domains of life.

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