Receptor Tyrosine Kinases in Drosophila Development | Zendy

Richelle Sopko | Zendy; Norbert Perrimon | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Receptor Tyrosine Kinases in Drosophila Development

Author(s) -

Richelle Sopko,

Norbert Perrimon

Publication year - 2013

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a009050

Subject(s) - receptor tyrosine kinase , biology , ror1 , receptor protein tyrosine kinases , tyrosine kinase , tyrosine phosphorylation , microbiology and biotechnology , protein tyrosine phosphatase , tyrosine , jak stat signaling pathway , sh2 domain , proto oncogene tyrosine protein kinase src , kinase , platelet derived growth factor receptor , signal transduction , receptor , genetics , biochemistry , growth factor

Tyrosine phosphorylation plays a significant role in a wide range of cellular processes. The Drosophila genome encodes more than 20 receptor tyrosine kinases and extensive studies in the past 20 years have illustrated their diverse roles and complex signaling mechanisms. Although some receptor tyrosine kinases have highly specific functions, others strikingly are used in rather ubiquitous manners. Receptor tyrosine kinases regulate a broad expanse of processes, ranging from cell survival and proliferation to differentiation and patterning. Remarkably, different receptor tyrosine kinases share many of the same effectors and their hierarchical organization is retained in disparate biological contexts. In this comprehensive review, we summarize what is known regarding each receptor tyrosine kinase during Drosophila development. Astonishingly, very little is known for approximately half of all Drosophila receptor tyrosine kinases.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research