Structure-Function Relationships of ErbB RTKs in the Plasma Membrane of Living Cells | Zendy

D. J. ArndtJovin | Zendy; Michelle Botelho Caarls | Zendy; Thomas M. Jovin | Zendy

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Structure-Function Relationships of ErbB RTKs in the Plasma Membrane of Living Cells

Author(s) -

D. J. ArndtJovin,

Michelle Botelho Caarls,

Thomas M. Jovin

Publication year - 2014

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a008961

Subject(s) - receptor tyrosine kinase , biology , microbiology and biotechnology , erbb , g protein coupled receptor , receptor protein tyrosine kinases , receptor , signal transduction , biochemistry

We review the states of the ErbB family of receptor tyrosine kinases (RTKs), primarily the EGF receptor (EGFR, ErbB1, HER1) and the orphan receptor ErbB2 as they exist in living mammalian cells, focusing on four main aspects: (1) aggregation state and distribution in the plasma membrane; (2) conformational features of the receptors situated in the plasma membrane, compared to the crystallographic structures of the isolated extracellular domains; (3) coupling of receptor disposition on filopodia with the transduction of signaling ligand gradients; and (4) ligand-independent receptor activation by application of a magnetic field

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