Apoptotic and Nonapoptotic Caspase Functions in Animal Development | Zendy

Masako Miura | Zendy

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Apoptotic and Nonapoptotic Caspase Functions in Animal Development

Author(s) -

Masako Miura

Publication year - 2012

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a008664

Subject(s) - biology , microbiology and biotechnology , apoptosis , caspase , programmed cell death , signal transduction , cell growth , cell , caspase 3 , caspase 2 , biochemistry

A developing animal is exposed to both intrinsic and extrinsic stresses. One stress response is caspase activation. Caspase activation not only controls apoptosis but also proliferation, differentiation, cell shape, and cell migration. Caspase activation drives development by executing cell death or nonapoptotic functions in a cell-autonomous manner, and by secreting signaling molecules or generating mechanical forces, in a noncell autonomous manner.

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