Primordial Germ Cells in Mice | Zendy

Mitinori Saitou | Zendy; Masashi Yamaji | Zendy

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Primordial Germ Cells in Mice

Author(s) -

Mitinori Saitou,

Masashi Yamaji

Publication year - 2012

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a008375

Subject(s) - reprogramming , biology , germ cell , epigenetics , induced pluripotent stem cell , microbiology and biotechnology , germ line development , epigenesis , germ , population , stem cell , cellular differentiation , genetics , embryonic stem cell , cell , dna methylation , gene expression , gene , demography , sociology

Germ cell development creates totipotency through genetic as well as epigenetic regulation of the genome function. Primordial germ cells (PGCs) are the first germ cell population established during development and are immediate precursors for both the oocytes and spermatogonia. We here summarize recent findings regarding the mechanism of PGC development in mice. We focus on the transcriptional and signaling mechanism for PGC specification, potential pluripotency, and epigenetic reprogramming in PGCs and strategies for the reconstitution of germ cell development using pluripotent stem cells in culture. Continued studies on germ cell development may lead to the generation of totipotency in vitro, which should have a profound influence on biological science as well as on medicine.

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