Branching Morphogenesis: From Cells to Organs and Back | Zendy

Amanda Ochoa-Espinosa | Zendy; Markus Affolter | Zendy

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Branching Morphogenesis: From Cells to Organs and Back

Author(s) -

Amanda Ochoa-Espinosa,

Markus Affolter

Publication year - 2012

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a008243

Subject(s) - biology , morphogenesis , multicellular organism , branching (polymer chemistry) , complementation , anatomy , microbiology and biotechnology , evolutionary biology , phenotype , gene , genetics , materials science , composite material

Many animal organs, such as the lung, the kidney, the mammary gland, and the vasculature, consist of branched tubular structures that arise through a process known as "branching morphogenesis" that results from the remodeling of epithelial or endothelial sheaths into multicellular tubular networks. In recent years, the combination of molecular biology, forward and reverse genetic approaches, and their complementation by live imaging has started to unravel rules and mechanisms controlling branching processes in animals. Common patterns of branch formation spanning diverse model systems are beginning to emerge that might reflect unifying principles of tubular organ formation.

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