Wnt Signaling in Neuromuscular Junction Development | Zendy

Kate Koles | Zendy; Vivian Budnik | Zendy

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Wnt Signaling in Neuromuscular Junction Development

Author(s) -

Kate Koles,

Vivian Budnik

Publication year - 2012

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a008045

Subject(s) - biology , wnt signaling pathway , vertebrate , microbiology and biotechnology , neuromuscular junction , function (biology) , neuroscience , signal transduction , cell fate determination , embryonic stem cell , nervous system , cell signaling , genetics , gene , transcription factor

Wnt proteins are best known for their profound roles in cell patterning, because they are required for the embryonic development of all animal species studied to date. Besides regulating cell fate, Wnt proteins are gaining increasing recognition for their roles in nervous system development and function. New studies indicate that multiple positive and negative Wnt signaling pathways take place simultaneously during the formation of vertebrate and invertebrate neuromuscular junctions. Although some Wnts are essential for the formation of NMJs, others appear to play a more modulatory role as part of multiple signaling pathways. Here we review the most recent findings regarding the function of Wnts at the NMJ from both vertebrate and invertebrate model systems.

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