Wnt Signaling in Vertebrate Axis Specification | Zendy

Hiroki Hikasa | Zendy; Sergei Y. Sokol | Zendy

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Wnt Signaling in Vertebrate Axis Specification

Author(s) -

Hiroki Hikasa,

Sergei Y. Sokol

Publication year - 2012

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a007955

Subject(s) - wnt signaling pathway , biology , zebrafish , xenopus , vertebrate , microbiology and biotechnology , cell fate determination , embryonic stem cell , developmental biology , signal transduction , embryogenesis , gastrulation , embryo , polarity in embryogenesis , genetics , gene , transcription factor

The Wnt pathway is a major embryonic signaling pathway that controls cell proliferation, cell fate, and body-axis determination in vertebrate embryos. Soon after egg fertilization, Wnt pathway components play a role in microtubule-dependent dorsoventral axis specification. Later in embryogenesis, another conserved function of the pathway is to specify the anteroposterior axis. The dual role of Wnt signaling in Xenopus and zebrafish embryos is regulated at different developmental stages by distinct sets of Wnt target genes. This review highlights recent progress in the discrimination of different signaling branches and the identification of specific pathway targets during vertebrate axial development.

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