Wnt/Wingless Signaling in Drosophila | Zendy

Sharan Swarup | Zendy; Esther M. Verheyen | Zendy

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Wnt/Wingless Signaling in Drosophila

Author(s) -

Sharan Swarup,

Esther M. Verheyen

Publication year - 2012

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a007930

Subject(s) - biology , drosophila (subgenus) , wnt signaling pathway , evolutionary biology , microbiology and biotechnology , zoology , computational biology , signal transduction , genetics , gene

The Wingless (Wg) pathway represents one of the best-characterized intercellular signaling networks. Studies performed in Drosophila over the last 30 years have contributed to our understanding of the role of Wg signaling in the regulation of tissue growth, polarity, and patterning. These studies have revealed mechanisms conserved in the vertebrate Wnt pathways and illustrate the elegance of using the Drosophila model to understand evolutionarily conserved modes of gene regulation. In this article, we describe the function of Wg signaling in patterning the Drosophila embryonic epidermis and wing imaginal disc. As well, we present an overview of the establishment of the Wg morphogen gradient and discuss the differential modes of Wg-regulated gene expression.

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