Frizzled and LRP5/6 Receptors for Wnt/ -Catenin Signaling | Zendy

Bryan T. MacDonald | Zendy; Xi He | Zendy

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Frizzled and LRP5/6 Receptors for Wnt/ -Catenin Signaling

Author(s) -

Bryan T. MacDonald,

Xi He

Publication year - 2012

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a007880

Subject(s) - frizzled , dishevelled , wnt signaling pathway , lrp5 , biology , lrp6 , microbiology and biotechnology , receptor , signal transduction , phosphorylation , beta catenin , biochemistry

Frizzled and LRP5/6 are Wnt receptors that upon activation lead to stabilization of cytoplasmic β-catenin. In this study, we review the current knowledge of these two families of receptors, including their structures and interactions with Wnt proteins, and signaling mechanisms from receptor activation to the engagement of intracellular partners Dishevelled and Axin, and finally to the inhibition of β-catenin phosphorylation and ensuing β-catenin stabilization.

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