Historical Overview of Immunological Tolerance | Zendy

R H Schwartz | Zendy

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Historical Overview of Immunological Tolerance

Author(s) -

R H Schwartz

Publication year - 2012

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a006908

Subject(s) - biology , autoimmunity , process (computing) , self tolerance , property (philosophy) , immune system , cognitive science , computational biology , immunology , neuroscience , epistemology , computer science , psychology , philosophy , operating system

A fundamental property of the immune system is its ability to mediate self-defense with a minimal amount of collateral damage to the host. The system uses several different mechanisms to achieve this goal, which is collectively referred to as the "process of immunological tolerance." This article provides an introductory historical overview to these various mechanisms, which are discussed in greater detail throughout this collection, and then briefly describes what happens when this process fails, a state referred to as "autoimmunity."

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