Organization of SNAREs within the Golgi Stack | Zendy

Joerg Malsam | Zendy; Thomas Söllner | Zendy

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Organization of SNAREs within the Golgi Stack

Author(s) -

Joerg Malsam,

Thomas Söllner

Publication year - 2011

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a005249

Subject(s) - golgi apparatus , biology , vesicle , lipid bilayer fusion , microbiology and biotechnology , transport protein , function (biology) , vesicle fusion , vesicular transport proteins , vesicular transport protein , secretory pathway , endosome , membrane , synaptic vesicle , biochemistry , endoplasmic reticulum , vacuolar protein sorting , intracellular

Antero- and retrograde cargo transport through the Golgi requires a series of membrane fusion events. Fusion occurs at the cis- and trans-side and along the rims of the Golgi stack. Four functional SNARE complexes have been identified mediating lipid bilayer merger in the Golgi. Their function is tightly controlled by a series of reactions involving vesicle tethering and SM proteins. This network of protein interactions spatially and temporally determines the specificity of transport vesicle targeting and fusion within the Golgi.

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