Calcium Oscillations | Zendy

Geneviève Dupont | Zendy; Laurent Combettes | Zendy; Gary S. Bird | Zendy; James W. Putney | Zendy

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Calcium Oscillations

Author(s) -

Geneviève Dupont,

Laurent Combettes,

Gary S. Bird,

James W. Putney

Publication year - 2010

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a004226

Subject(s) - calcium , biology , calcium signaling , t type calcium channel , calcium in biology , mechanism (biology) , extracellular , voltage dependent calcium channel , calcium atpase , biophysics , microbiology and biotechnology , intracellular , biochemistry , chemistry , physics , enzyme , atpase , organic chemistry , quantum mechanics

Calcium signaling results from a complex interplay between activation and inactivation of intracellular and extracellular calcium permeable channels. This complexity is obvious from the pattern of calcium signals observed with modest, physiological concentrations of calcium-mobilizing agonists, which typically present as sequential regenerative discharges of stored calcium, a process referred to as calcium oscillations. In this review, we discuss recent advances in understanding the underlying mechanism of calcium oscillations through the power of mathematical modeling. We also summarize recent findings on the role of calcium entry through store-operated channels in sustaining calcium oscillations and in the mechanism by which calcium oscillations couple to downstream effectors.

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