Nodal Morphogens | Zendy

Alexander F. Schier | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Nodal Morphogens

Author(s) -

Alexander F. Schier

Publication year - 2009

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a003459

Subject(s) - nodal , morphogen , nodal signaling , biology , mesoderm , endoderm , microbiology and biotechnology , ectoderm , decapentaplegic , nodal analysis , embryonic stem cell , anatomy , embryogenesis , embryo , transcription factor , gastrulation , genetics , gene , enhancer , engineering , electrical engineering

Nodal signals belong to the TGF-beta superfamily and are essential for the induction of mesoderm and endoderm and the determination of the left-right axis. Nodal signals can act as morphogens-they have concentration-dependent effects and can act at a distance from their source of production. Nodal and its feedback inhibitor Lefty form an activator/inhibitor pair that behaves similarly to postulated reaction-diffusion models of tissue patterning. Nodal morphogen activity is also regulated by microRNAs, convertases, TGF-beta signals, coreceptors, and trafficking factors. This article describes how Nodal morphogens pattern embryonic fields and discusses how Nodal morphogen signaling is modulated.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research