Planar Cell Polarity Signaling: The Developing Cell's Compass | Zendy

Eszter K. Vladar | Zendy; Dragana Antic | Zendy; Jeffrey D. Axelrod | Zendy

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Planar Cell Polarity Signaling: The Developing Cell's Compass

Author(s) -

Eszter K. Vladar,

Dragana Antic,

Jeffrey D. Axelrod

Publication year - 2009

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a002964

Subject(s) - biology , polarity (international relations) , microbiology and biotechnology , cell polarity , subcellular localization , cell , asymmetry , genetics , cytoplasm , physics , quantum mechanics

Cells of many tissues acquire cellular asymmetry to execute their physiologic functions. The planar cell polarity system, first characterized in Drosophila, is important for many of these events. Studies in Drosophila suggest that an upstream system breaks cellular symmetry by converting tissue gradients to subcellular asymmetry, whereas a downstream system amplifies subcellular asymmetry and communicates polarity between cells. In this review, we discuss apparent similarities and differences in the mechanism that controls PCP as it has been adapted to a broad variety of morphological cellular asymmetries in various organisms.

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