ITAM-mediated Signaling by the T-Cell Antigen Receptor | Zendy

Paul E. Love | Zendy; Sandra M. Hayes | Zendy

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ITAM-mediated Signaling by the T-Cell Antigen Receptor

Author(s) -

Paul E. Love,

Sandra M. Hayes

Publication year - 2010

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a002485

Subject(s) - immunoreceptor tyrosine based activation motif , t cell receptor , biology , signal transduction , effector , receptor , microbiology and biotechnology , cytoplasm , antigen , t cell , computational biology , immunology , genetics , immune system

Signal transduction by the T-cell antigen receptor (TCR) is initiated by phosphorylation of conserved motifs (ITAMs) contained within the cytoplasmic domains of the invariant subunits. TCR complexes contain a total of 10 ITAMs and this unusual configuration has prompted studies of the role of specific ITAMs, or of ITAM multiplicity, in regulating TCR-directed developmental and effector responses. Here, we summarize data generated during the past two decades and discuss how these findings have in some cases resolved, and in others complicated, outstanding questions relating to the function of TCR ITAMs.

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