ZAP-70: An Essential Kinase in T-cell Signaling | Zendy

Haopeng Wang | Zendy; Theresa A. Kadlecek | Zendy; Byron B. AuYeung | Zendy; Henry Goodfellow | Zendy; Li Yang Hsu | Zendy; Tanya S. Freedman | Zendy; Arthur Weiss | Zendy

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ZAP-70: An Essential Kinase in T-cell Signaling

Author(s) -

Haopeng Wang,

Theresa A. Kadlecek,

Byron B. AuYeung,

Henry Goodfellow,

Li Yang Hsu,

Tanya S. Freedman,

Arthur Weiss

Publication year - 2010

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a002279

Subject(s) - biology , microbiology and biotechnology , signal transduction , function (biology) , kinase , tyrosine kinase , t cell receptor , cytoplasm , t cell , immunology , immune system

ZAP-70 is a cytoplasmic protein tyrosine kinase that plays a critical role in the events involved in initiating T-cell responses by the antigen receptor. Here we review the structure of ZAP-70, its regulation, its role in development and in disease. We also describe a model experimental system in which ZAP-70 function can be interrupted by a small chemical inhibitor.

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