Membrane Organization and Dynamics in Cell Polarity
Author(s) -
Kelly Orlando,
Wei Guo
Publication year - 2009
Publication title -
cold spring harbor perspectives in biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.011
H-Index - 173
ISSN - 1943-0264
DOI - 10.1101/cshperspect.a001321
Subject(s) - cell polarity , biology , polarity (international relations) , microbiology and biotechnology , membrane , chemotaxis , cell membrane , membrane protein , cell , biochemistry , receptor
The establishment and maintenance of cell polarity is important to a wide range of biological processes ranging from chemotaxis to embryogenesis. An essential feature of cell polarity is the asymmetric organization of proteins and lipids in the plasma membrane. In this article, we discuss how polarity regulators such as small GTP-binding proteins and phospholipids spatially and kinetically control vesicular trafficking and membrane organization. Conversely, we discuss how membrane trafficking contributes to cell polarization through delivery of polarity determinants and regulators to the plasma membrane.
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