Polarity in Stem Cell Division: Asymmetric Stem Cell Division in Tissue Homeostasis | Zendy

Yukiko Yamashita | Zendy; Hebao Yuan | Zendy; Jun Cheng | Zendy; Alan Hunt | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Polarity in Stem Cell Division: Asymmetric Stem Cell Division in Tissue Homeostasis

Author(s) -

Yukiko Yamashita,

Hebao Yuan,

Jun Cheng,

Alan Hunt

Publication year - 2009

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a001313

Subject(s) - stem cell , biology , microbiology and biotechnology , asymmetric cell division , cell division , adult stem cell , context (archaeology) , niche , cellular differentiation , endothelial stem cell , cell , genetics , biochemistry , in vitro , paleontology , gene

Many adult stem cells divide asymmetrically to balance self-renewal and differentiation, thereby maintaining tissue homeostasis. Asymmetric stem cell divisions depend on asymmetric cell architecture (i.e., cell polarity) within the cell and/or the cellular environment. In particular, as residents of the tissues they sustain, stem cells are inevitably placed in the context of the tissue architecture. Indeed, many stem cells are polarized within their microenvironment, or the stem cell niche, and their asymmetric division relies on their relationship with the microenvironment. Here, we review asymmetric stem cell divisions in the context of the stem cell niche with a focus on Drosophila germ line stem cells, where the nature of niche-dependent asymmetric stem cell division is well characterized.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research