Morphogen Gradient Formation | Zendy

Ortrud Wartlick | Zendy; Anna Kicheva | Zendy; Marcos GonzálezGaitán | Zendy

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Morphogen Gradient Formation

Author(s) -

Ortrud Wartlick,

Anna Kicheva,

Marcos GonzálezGaitán

Publication year - 2009

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a001255

Subject(s) - morphogen , biology , microbiology and biotechnology , evolutionary biology , biochemistry , gene

How morphogen gradients are formed in target tissues is a key question for understanding the mechanisms of morphological patterning. Here, we review different mechanisms of morphogen gradient formation from theoretical and experimental points of view. First, a simple, comprehensive overview of the underlying biophysical principles of several mechanisms of gradient formation is provided. We then discuss the advantages and limitations of different experimental approaches to gradient formation analysis.

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