Nuclear Ataxias | Zendy

Harry T. Orr | Zendy

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Nuclear Ataxias

Author(s) -

Harry T. Orr

Publication year - 2010

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a000786

Subject(s) - biology , neuroscience , mechanism (biology) , nucleus , cell nucleus , function (biology) , microbiology and biotechnology , philosophy , epistemology

Historically basic neuroscience research has made several important contributions to the cell biology of the nucleus, in particular the elucidation of nuclear structures and compartments. As research progressed towards elucidating the mechanism of neurological disease at the cellular and molecular levels, it is now providing insight into the importance and basis of coordination of nuclear pathways within the nucleus and with other cellular compartments. Ataxias, lethal neurodegenerative diseases that are distinguished by a progressive loss of motor coordination, stem from disruption of nuclear function.

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