RNA Processing and Export | Zendy

Sami Hocine | Zendy; Robert H. Singer | Zendy; David Grünwald | Zendy

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RNA Processing and Export

Author(s) -

Sami Hocine,

Robert H. Singer,

David Grünwald

Publication year - 2010

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a000752

Subject(s) - biology , rna processing , messenger rna , rna splicing , rna , translation (biology) , mature messenger rna , microbiology and biotechnology , precursor mrna , rna binding protein , nuclear export signal , cytoplasm , post transcriptional modification , protein biosynthesis , computational biology , genetics , gene

Messenger RNAs undergo 5\u27 capping, splicing, 3\u27-end processing, and export before translation in the cytoplasm. It has become clear that these mRNA processing events are tightly coupled and have a profound effect on the fate of the resulting transcript. This processing is represented by modifications of the pre-mRNA and loading of various protein factors. The sum of protein factors that stay with the mRNA as a result of processing is modified over the life of the transcript, conferring significant regulation to its expression

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