DNA Damage Response | Zendy

Giuseppina GigliaMari | Zendy; Angelika Zotter | Zendy; Wim Vermeulen | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

DNA Damage Response

Author(s) -

Giuseppina GigliaMari,

Angelika Zotter,

Wim Vermeulen

Publication year - 2010

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a000745

Subject(s) - biology , dna re replication , dna damage , chromatin , dna replication , dna repair , dna , microbiology and biotechnology , genetics , control of chromosome duplication , computational biology , transcription (linguistics) , linguistics , philosophy

textabstractStructural changes to DNA severely affect its functions, such as replication and transcription, and play a major role in age-related diseases and cancer. A complicated and entangled network ofDNA damage response (DDR) mechanisms, including multiple DNA repair pathways, damage tolerance processes, and cell-cycle checkpoints safeguard genomic integrity. Like transcription and replication, DDR is a chromatin-associated process that is generally tightly controlled in time and space. As DNA damage can occur at any time on any genomic location, a specialized spatio-temporal orchestration of this defense apparatus is required

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research