Mesenchymal Stem Cells: “Repair Cells” that Serve Wounds and Cancer? | Zendy

Jürgen Dittmer | Zendy

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Mesenchymal Stem Cells: “Repair Cells” that Serve Wounds and Cancer?

Author(s) -

Jürgen Dittmer

Publication year - 2010

Publication title -

the scientific world journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.453

H-Index - 93

eISSN - 2356-6140

pISSN - 1537-744X

DOI - 10.1100/tsw.2010.119

Subject(s) - mesenchymal stem cell , cancer , cancer research , cancer cell , regeneration (biology) , medicine , wound healing , breast cancer , cancer stem cell , stem cell transplantation for articular cartilage repair , biology , pathology , immunology , microbiology and biotechnology , adult stem cell , endothelial stem cell , in vitro , biochemistry

Bone marrow-derived mesenchymal stem cells (MSCs) colonize wounds apparently to facilitate tissue regeneration. Remarkably, they are able to differentiate into cells that are specifically needed to repair the injured tissue. However, MSCs are also attracted to cancers, likely because MSCs mistake cancers for wounds, and may there influence the proliferative and metastatic activities of the cancer cells. Recently, it was demonstrated that MSCs increase the motility of breast cancer cells by activating ADAM10, a protease which regulates epithelial cell-cell adhesion and which is often overexpressed in cancer. By targeting ADAM10 MSCs may promote progression of breast cancer. Cancers may mislead MSCs and use them for their own 'needs.'

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