Open AccessTranscription activation in bacteria: ancient and modern
Author(s) -
Stephen J. W. Busby
Publication year - 2019
Publication title -
microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 179
eISSN - 1465-2080
pISSN - 1350-0872
DOI - 10.1099/mic.0.000783
Subject(s) - transcription (linguistics) , promoter , biology , bacterial transcription , bacteria , transcription factor , gene , genetics , general transcription factor , regulation of gene expression , microbiology and biotechnology , gene expression , philosophy , linguistics
Regulatory interactions at the lac promoter.Activation of the transcription of genes is central to many processes of adaptation and differentiation in bacteria. Here, I review the molecular mechanisms by which transcription factors can activate the initiation of specific transcripts at bacterial promoters. The story is presented in the context of Marjory Stephenson's pioneering work on enzymatic adaptation in bacteria, and sets the different mechanisms in the greater context of how transcription regulatory mechanisms evolved.