Open AccessFrom genotype to phenotype: adaptations of Pseudomonas aeruginosa to the cystic fibrosis environment
Author(s) -
Laura Camus,
François Vandenesch,
Karen Moreau
Publication year - 2021
Publication title -
microbial genomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.476
H-Index - 28
ISSN - 2057-5858
DOI - 10.1099/mgen.0.000513
Subject(s) - pseudomonas aeruginosa , cystic fibrosis , phenotype , genotype , biology , transcriptome , microbiology and biotechnology , chronic infection , gene , genetics , bacteria , gene expression , immune system
Pseudomonas aeruginosa is one of the main microbial species colonizing the lungs of cystic fibrosis patients and is responsible for the decline in respiratory function. Despite the hostile pulmonary environment, P. aeruginosa is able to establish chronic infections thanks to its strong adaptive capacity. Various longitudinal studies have attempted to compare the strains of early infection with the adapted strains of chronic infection. Thanks to new '-omics' techniques, convergent genetic mutations, as well as transcriptomic and proteomic dysregulations have been identified. As a consequence of this evolution, the adapted strains of P. aeruginosa have particular phenotypes that promote persistent infection.