Open AccessFirst description of IncX3 NDM-5-producing plasmid within Escherichia coli ST448 in Mali
Author(s) -
Anaëlle Muggeo,
Aminata Maiga,
Ibrahim Maïga,
Lucien Brasme,
Oumar Agaly Dicko,
Christophe de Champs,
Thomas Guillard
Publication year - 2020
Publication title -
journal of medical microbiology/journal of medical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.91
H-Index - 117
eISSN - 1473-5644
pISSN - 0022-2615
DOI - 10.1099/jmm.0.001182
Subject(s) - enterobacteriaceae , plasmid , escherichia coli , microbiology and biotechnology , biology , epidemiology , medicine , gene , genetics
Carbapenem resistance in Enterobacteriaceae has become an increasingly worrying threat. So far, no epidemiological data regarding NDM-producing enterobacterial isolates has been available on these strains in West Africa. The aim of this study was to seek for carbapenemase-producing Enterobacteriaceae clinical strains isolated in Bamako Teaching Hospital in Mali. Of 50 strains isolated between May 2016 and September 2016, we found a ST448 E. coli harbouring an IncX3 plasmid with bla NDM-5 embedded in the Δ ISAba125-ble MBL structure. This study reports the first description of NDM-5 in Mali isolated in an undescribed ST E. coli in West Africa.