Open AccessIsolation and characterization of Siphoviridae phage infecting extensively drug-resistant Acinetobacter baumannii and evaluation of therapeutic efficacy in vitro and in vivo
Author(s) -
Phitchayapak Wintachai,
Ampapan Naknaen,
Rattanaruji Pomwised,
Supayang Piyawan Voravuthikunchai,
Duncan R. Smith
Publication year - 2019
Publication title -
journal of medical microbiology/journal of medical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.91
H-Index - 117
eISSN - 1473-5644
pISSN - 0022-2615
DOI - 10.1099/jmm.0.001002
Subject(s) - siphoviridae , acinetobacter baumannii , phage therapy , microbiology and biotechnology , antimicrobial , biology , in vivo , biofilm , antibiotics , bacteriophage , bacteria , pseudomonas aeruginosa , escherichia coli , biochemistry , genetics , gene
Extensively drug-resistant (XDR) strains of Acinetobacter baumannii are being reported worldwide, and they are associated with high morbidity and mortality rates. These strains are considered to be the highest priority for the development of new antibacterial agents. Therefore, we aimed to develop an effective alternative antimicrobial agent.