Antimicrobial peptides prevent bacterial biofilm formation on the surface of polymethylmethacrylate bone cement | Zendy

Andrea Volejníková | Zendy; Pavel Melicherčík | Zendy; Ondřej Nešuta | Zendy; Eva Vaňková | Zendy; Lucie Bednářová | Zendy; Jiří Rybáček | Zendy; Václav Čeřovský | Zendy

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Antimicrobial peptides prevent bacterial biofilm formation on the surface of polymethylmethacrylate bone cement

Author(s) -

Andrea Volejníková,

Pavel Melicherčík,

Ondřej Nešuta,

Eva Vaňková,

Lucie Bednářová,

Jiří Rybáček,

Václav Čeřovský

Publication year - 2019

Publication title -

journal of medical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.91

H-Index - 117

eISSN - 1473-5644

pISSN - 0022-2615

DOI - 10.1099/jmm.0.001000

Subject(s) - biofilm , antimicrobial , microbiology and biotechnology , bone cement , cement , antimicrobial peptides , chemistry , bacteria , materials science , biology , composite material , genetics

Antibiotic-loaded polymethylmethacrylate-based bone cement has been implemented in orthopaedics to cope with implant-related infections associated with the formation of bacterial biofilms. In the context of emerging bacterial resistance to current antibiotics, we examined the efficacy of short antimicrobial peptide-loaded bone cement in inhibiting bacterial adhesion and consequent biofilm formation on its surface.

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