Open AccessAntimicrobial peptides prevent bacterial biofilm formation on the surface of polymethylmethacrylate bone cement
Author(s) -
Andrea Volejníková,
Pavel Melicherčík,
Ondřej Nešuta,
Eva Vaňková,
Lucie Bednářová,
Jiří Rybáček,
Václav Čeřovský
Publication year - 2019
Publication title -
journal of medical microbiology/journal of medical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.91
H-Index - 117
eISSN - 1473-5644
pISSN - 0022-2615
DOI - 10.1099/jmm.0.001000
Subject(s) - biofilm , staphylococcus epidermidis , microbiology and biotechnology , antimicrobial , antibiotics , bacteria , staphylococcus aureus , antimicrobial peptides , pseudomonas aeruginosa , chemistry , antibiotic resistance , biology , genetics
Antibiotic-loaded polymethylmethacrylate-based bone cement has been implemented in orthopaedics to cope with implant-related infections associated with the formation of bacterial biofilms. In the context of emerging bacterial resistance to current antibiotics, we examined the efficacy of short antimicrobial peptide-loaded bone cement in inhibiting bacterial adhesion and consequent biofilm formation on its surface.