Open AccessTigecycline and inducible clindamycin resistance in clinical isolates of methicillin-resistant Staphylococcus aureus from Terengganu, Malaysia
Author(s) -
Ainal Mardziah Che Hamzah,
Chew Chieng Yeo,
Suat Moi Puah,
Kek Heng Chua,
Nor Iza A. Rahman,
Fatimah Haslina Abdullah,
Norlela Othman,
C. H. Chew
Publication year - 2019
Publication title -
journal of medical microbiology/journal of medical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.91
H-Index - 117
eISSN - 1473-5644
pISSN - 0022-2615
DOI - 10.1099/jmm.0.000993
Subject(s) - tigecycline , clindamycin , staphylococcus aureus , microbiology and biotechnology , methicillin resistant staphylococcus aureus , multiple drug resistance , linezolid , antibiotic resistance , biology , antibiotics , medicine , vancomycin , bacteria , genetics
The spread of multidrug-resistant Staphylococcus aureus is a public health concern. The inducible macrolide-lincosamide-streptogrammin B (iMLS B ) phenotype (or inducible clindamycin resistance) is associated with false clindamycin susceptibility in routine laboratory testing and may lead to treatment failure. Tigecycline resistance remains rare in S. aureus worldwide. This study aims to determine the antimicrobial susceptibility profiles of clinical isolates of S. aureus obtained from the main tertiary hospital in Terengganu state, Malaysia, from July 2016 to June 2017. The antimicrobial susceptibilities of 90 methicillin-resistant S. aureus (MRSA) and 109 methicillin-susceptible S. aureus (MSSA) isolates were determined by disc diffusion with the iMLS B phenotype determined by D-test. Multidrug resistance (MDR) and the iMLS B phenotype were more prevalent in MRSA (84.4 and 46.7 %, respectively) compared to MSSA isolates. All five tigecycline-resistant isolates were MRSA. The high incidence of MDR and the iMLS B phenotype and the emergence of tigecycline resistance in the Terengganu S. aureus isolates warrants continuous vigilance.