Open AccessSerum IgE and IgG reactivity to Aspergillus recombinant antigens in patients with cystic fibrosis
Author(s) -
Nada S. Alghamdi,
Richard Barton,
Mark H. Wilcox,
Daniel Peckham
Publication year - 2019
Publication title -
journal of medical microbiology/journal of medical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.91
H-Index - 117
eISSN - 1473-5644
pISSN - 0022-2615
DOI - 10.1099/jmm.0.000991
Subject(s) - allergic bronchopulmonary aspergillosis , aspergillus fumigatus , immunoglobulin e , antigen , immunology , aspergillus , recombinant dna , cystic fibrosis , aspergillosis , antibody , medicine , microbiology and biotechnology , biology , biochemistry , gene
The diagnosis of aspergillosis in cystic fibrosis (CF) patients remains a challenge due to overlapping features of both diseases. This is further complicated by inconsistent antibody reactivity to the currently used crude antigen, which has led a more focused evaluation of the efficacy of IgE response to a number of pure Aspergillus fumigatus recombinant proteins in patients with CF and asthma. In this study, we dissected the IgE and IgG responses to multiple A. fumigatus recombinant antigens in CF patients with different Aspergillus diseases.